The REST Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NRSF, and REST. This antibody recognizes Human antigen. The REST Antibody has been validated for the following applications: Western Blot.
Description
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier